Insight 13

Alopecia areata and its changing course

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Published

A patch can fill in while another area begins losing hair. Eyebrows or a beard may change while the scalp looks stable. Alopecia areata can have a changing course that makes one photograph an incomplete record.

The assessment needs to establish the areas affected, recent activity and the effect on daily life. Those details help set treatment priorities.

Recognize the range of presentations

Alopecia areata is an immune-mediated condition affecting hair follicles. It often causes patches, but diffuse forms can cause widespread loss without the familiar round pattern. Studies describe these less obvious presentations.1

Scalp hair, eyebrows, eyelashes and body hair can be affected differently. A scalp score alone cannot describe the full concern of someone losing lashes or beard hair.2

Other causes can produce patches or broken hairs. The diagnosis needs the history and examination together, with testing when it answers a relevant question.

Follow activity and recovery separately

New loss and regrowth can occur at the same time in different areas. Record the sites, when the changes began and any earlier episodes. This gives follow-up a clearer picture than a general impression that the hair is better or worse.

Recovery does not establish that future episodes are impossible. Continued loss also deserves review of whether the current treatment fits the extent and course of disease.

Regrowth in one area and new loss elsewhere can be part of the same changing condition.

Match treatment to the problem

Localized disease and extensive loss lead to different treatment discussions. Age, medical history, previous response and the affected areas matter alongside the amount of scalp hair missing.

Trials of baricitinib demonstrated regrowth in adults with severe alopecia areata.3 That evidence supports a defined population and treatment. Children and people with limited patches need recommendations suited to their age and extent of loss.

A recommendation should explain the preferred treatment, expected timing of assessment, monitoring and alternatives. Prescription decisions remain with the treating prescriber.

Include the person's priorities

A small visible area can have a substantial practical effect. Eyebrow loss, difficulty using camouflage and concern about repeated episodes deserve attention. The plan should also consider time, cost and the burden of ongoing treatment.

Cosmetic support can help while the condition is assessed or treated. It should fit the skin and hair situation without creating additional tension or irritation.

Prepare a useful record

Bring photographs of previous episodes, treatments used and any changes in brows, lashes, beard or nails. The next step should address current activity and the outcome that matters most to the person.

References

  1. Alessandrini A, Starace M, Bruni F, et al. Alopecia Areata Incognita and Diffuse Alopecia Areata: Clinical, Trichoscopic, Histopathological, and Therapeutic Features of a 5-Year Study. Dermatol Pract Concept. 2019;9:272-277. doi:10.5826/dpc.0904a05. Return to text ↑
  2. Nguyen B, Hu JK, Tosti A. Eyebrow and Eyelash Alopecia: A Clinical Review. Am J Clin Dermatol. 2023;24:55-67. doi:10.1007/s40257-022-00729-5. Return to text ↑
  3. King B, Ohyama M, Kwon O, et al. Two Phase 3 Trials of Baricitinib for Alopecia Areata. N Engl J Med. 2022;386:1687-1699. doi:10.1056/NEJMoa2110343. Return to text ↑

Medical disclaimer: FHI Insights is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Consult a licensed healthcare professional regarding individual health concerns or treatment decisions.